Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble\ndrugs. ASDs of olanzapine (OLZ), which have a high melting point and low solubility, are performed\nusing a complicated process. Three-dimensional (3D) printing based on hot-melt pneumatic extrusion\n(HMPE) is a simplified method for producing ASDs. Unlike general 3D printing, printlet extrusion is\npossible without the preparation of drug-loaded filaments. By heating powder blends, direct fused\ndeposition modeling (FDM) printing through a nozzle is possible, and this step produces ASDs\nof drugs. In this study, we developed orodispersible films (ODFs) loaded with OLZ as a poorly\nwater-soluble drug. Various ratios of film-forming polymers and plasticizers were investigated\nto enhance the printability and optimize the printing temperature. Scanning electron microscopy\n(SEM) showed the surface morphology of the film for the optimization of the polymer carrier ratios.\nDifferential scanning calorimetry (DSC) was used to evaluate thermal properties. Powder X-ray\ndiffraction (PXRD) confirmed the physical form of the drug during printing. The 3D printed ODF\nformulations successfully loaded ASDs of OLZ using HMPE. Our ODFs showed fast disintegration\npatterns within 22 s, and rapidly dissolved and reached up to 88% dissolution within 5 min in\nthe dissolution test. ODFs fabricated using HMPE in a single process of 3D printing increased the\ndissolution rates of the poorly water-soluble drug, which could be a suitable formulation for fast\ndrug absorption. Moreover, this new technology showed prompt fabrication feasibility of various\nformulations and ASD formation of poorly water-soluble drugs as a single process. The immediate\ndissolution within a few minutes of ODFs with OLZ, an atypical antipsychotic, is preferred for drug\ncompliance and administration convenience.
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